GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs1577917 | 1 | rs9647603 | chr6:86639341 | SNHG5 | chr6:86386726-86388451:- | -0.55 | -10.02 | 3.91E-21 | Response to antipsychotic treatment |
| BLCA | cis | rs9309473 | 1 | rs9653557 | chr2:73795962 | ALMS1P | chr2:73872046-73912692:+ | 0.34 | 5.08 | 5.95E-7 | Metabolite levels |
| BLCA | cis | rs12220238 | 1 | rs9665468 | chr10:75938838 | ADK | chr10:75910965-76469059:+ | 0.3 | 4.45 | 1.12E-5 | Soluble interleukin-2 receptor subunit alpha |
| BLCA | cis | rs9665626 | 1 | rs9665626 | chr10:104300638 | SFXN2 | chr10:104474298-104498946:+ | 0.46 | 5.7 | 2.46E-8 | Schizophrenia |
| BLCA | cis | rs9894429 | 1 | rs9674872 | chr17:79581931 | TSPAN10 | chr17:79609349-79615778:+ | 0.49 | 8.84 | 3.52E-17 | Eye color traits |
| BLCA | cis | rs968567 | 1 | rs968567 | chr11:61595564 | FADS2 | chr11:61583728-61634825:+ | 0.38 | 4.41 | 1.35E-5 | Blood metabolite levels;Rheumatoid arthritis;Glycerophospholipid levels |
| BLCA | cis | rs3091242 | 1 | rs9689 | chr1:25688276 | RHD | chr1:25598981-25656935:+ | -0.48 | -8.41 | 8.47E-16 | Erythrocyte sedimentation rate |
| BLCA | cis | rs9894429 | 1 | rs9747349 | chr17:79584297 | TSPAN10 | chr17:79609349-79615778:+ | 0.49 | 8.84 | 3.52E-17 | Eye color traits |
| BLCA | cis | rs9894429 | 1 | rs9748176 | chr17:79584043 | TSPAN10 | chr17:79609349-79615778:+ | 0.49 | 8.8 | 4.7E-17 | Eye color traits |
| BLCA | cis | rs9371538 | 1 | rs975459 | chr6:151876909 | C6orf97 | chr6:151815175-151942327:+ | 0.28 | 4.07 | 5.63E-5 | Bone mineral density (spine) |
| BLCA | cis | rs9322193 | 1 | rs9767077 | chr6:150109615 | NUP43 | chr6:150045453-150067688:- | -0.28 | -4.54 | 7.64E-6 | Lung cancer |
| BLCA | cis | rs2243480 | 1 | rs9769882 | chr7:65642925 | CCT6P1 | chr7:65216092-65228661:+ | -0.35 | -4.71 | 3.52E-6 | Diabetic kidney disease |
| BLCA | cis | rs4237643 | 1 | rs9783304 | chr11:43660255 | HSD17B12 | chr11:43702143-43878160:+ | 0.43 | 7.08 | 7.06E-12 | Forced vital capacity |
| BLCA | cis | rs9783347 | 1 | rs9783347 | chr11:18384938 | GTF2H1 | chr11:18343816-18388590:+ | 0.29 | 5.55 | 5.44E-8 | Pancreatic cancer |
| BLCA | cis | rs10935120 | 1 | rs9809619 | chr3:134280948 | ANAPC13 | chr3:134196547-134204865:- | 0.49 | 7.74 | 8.99E-14 | Height |